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北海道大学 大学院医学研究院微生物部門免疫学分野
ワクチン研究開発拠点（IVRed)
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University
免疫学教室
2024
JE Tovar-Perez, Zhang S, Hodgeman W, Kapoor S, Rajendran P, Kobayashi KS ,Dashwood RH
Clin Epigenetics. 2024 Jun 24;16(1):83
Zhu B, Ouda R, Kasuga Y, de Figueiredo P, Kobayashi KS
NLRC5/MHC class I transactivator:A key target for immune escape by SARS-CoV-2
Bioessays. 2024 Apr;46(4):e2300109
Zhu B, Ouda R, An N, Tanaka T, Kobayashi KS
The balance between nuclear import and export of NLRC5 regulates MHC class I transactivation
J Biol Chem. 2024 Mar 20:107205. doi:10.1016/j.jbc.2024.107205
Cabello AL, Wells K, Peng W, Feng HQ, Wang J, Meyer DF, Noroy C, Zhao ES, Zhang H, Li X, Chang H, Gomez G, Mao Y, Patrick KL, Watson RO, Russell WK, YuA, Zhong J, Guo F, Li M, Zhou M, Qian X, Kobayashi KS, Song J, Panthee S, Mechref Y, Ficht TA, Qin QM, de Figueiredo P
Brucella-driven host N-glycome remodeling controls infection
Cell Host Microbe. 2024 Mar 20:S1931-3128(24)00083-0
Sun X, Watanabe T, Oda Y, Shen W, Ahmad A, Ouda R, de Figueiredo P, Kitamura H, Tanaka S, Kobayashi KS
Targeted demethylation and activation of NLRC5 augment cancer immunogenicity through MHC class I
Proc Natl Acad Sci USA. 2024 Feb 6;121(6):e2310821121
2023
Zhu B, Ouda R, de Figueiredo P, Kobayashi KS
ORF6, a repressor of the MHC class I pathway: New molecular target for SARS-CoV-2 drug discovery?
https://www.tandfonline.com/doi/full/10.1080/14728222.2023.2248377
Expert Opinion on Therapeutic Targets. 2023 27(8):639-644
Kasuga Y, Ouda R, Watanabe M, Sun X, Kimura M, Hatakeyama S, Kobayashi KS
Proc Natl Acad Sci USA. 2023 Jun 13; 120(24):e2218955120
Plocica J, Guo F, Das JK, Kobayashi KS, Ficht TA, Alaniz RC, Song J, de Figueiredo P
Engineering live attenuated vaccines: Old dogs learning new tricks.
J Transl Autoimmun. 2023 Mar 27;6:100198
2022
應田涼太、春日優介、坐間のゆり、小林弘一
新型コロナウイルスの細胞性免疫逃避メカニズム
バイオサイエンスとインダストリー, 2022 Vol.80 No.3, 254-255
應田涼太、吉濱小百合、春日優介、坐間のゆり、小林弘一
NLRC5のがんと免疫療法における役割
臨床免疫・アレルギー科, 77(1):114-120, 2022
Mathé J, Benhammadi M, Kobayashi KS, Brochu S, Perreault C
Regulation of MHC class I expression in lung epithelial cells during inflammation.
J Immunol 2022 Mar 1; 208(5):1021-1033
Chen YS, Li J, Neja S, Kapoor S, Tovar Perez JE, Tripathi C, Menon R, Jayaraman A, Lee K, Dashwood WM, Wang S, Zhang K, Kobayashi K, Rajendran P, Dashwood R
Cells. 2022 Feb 7;11(3):573
Das JK, Guo F, Hunt C, Steinmeyer S, Plocica JA, Kobayashi KS, Ding Y, Jayaraman A, Ficht TA, Alaniz RC, de Figueiredo P, Song J
Gut Microbes. 2022 Jan-Dec; 14(1):2143222
Guo F, Das JK, Kobayashi KS, Qin QM, A Ficht T, Alanis RC, Song J, FIgueiredo P
J Immunother Cancer. 2022 Jan 10(1):e003760
2021
Yoo JS, Sasaki M, Cho SX, Kasuga Y, Zhu B, Ouda R, Orba Y, Figueiredo P, Sawa H, Kobayashi KS
SARS-CoV-2 inhibits induction of the MHC class I pathway by targeting the STAT1-IRF1-NLRC5 axis
Nat Comm. 2021 12:6602
Kasuga Y, Zhu B, Jang KJ, Yoo JS
Innate immune sensing of coronavirus and viral evasion strategies.
Exp Mol Med. 2021 May 6;1-4
Yoshihama S, Cho SX, Yeung J, Pan X, Lizee G, Kongati K, Johnson VE, Kobayashi KS
NLRC5/CITA expression correlates with efficient response to checkpoint blockade immunotherapy
Scientific Reports. 2021 Feb 5; 11:3258
2020
Benhammadi M, Mathé J, Dumont-Lagacé M, Kobayashi KS, Gaboury L, Brochu S, Perreault C.
IFN-λ Enhances Constitutive Expression of MHC class I Molecules on Thymic Epithelial Cells.
J Immunol. 2020 Sept 1; 205(5):1268-1280
Cho SX, Vijayan S, Yoo JS, Watanabe T, Ouda R, An N, Kobayashi KS.
MHC class I transactivator NLRC5 in host immunity, cancer and beyond.
Immunology. 2020 July 7. doi: 10.1111/imm.13235
2019
Vijayan S, Sidiq T, Yousuf S, van den Elsen PJ, Kobayashi KS
Immunogenetics. 2019 Mar; 71(3):273-282
Chen T, Liu AB, Sun S, Akami NJ, Ross MC, Wang H, Zhang L, Reuhl K, Kobayashi K, Onishi JC, Zhao L, Yang CS
Mol Nut Food Res. 2019 Jan 22:e1801064
2018
應田涼太、尾野純也、吉濱小百合、小林弘一
細菌パターン認識受容体NOD2の腸管免疫における役割
臨床免疫・アレルギー科、70(5):497-502, 2018年
Nechama M, Kwon J, Wei S, Kyi AT, Welner RS, Ben-Dov IZ, Arredouani MS, Asara JM, Chen CH, Tsai CY, Nelson KF, Kobayashi KS, Israel E, Zhou XZ, Nicholson LK, Lu KP.
Nat Commun. 2018 Apr 23;9(1):1603.
Agudo, J., Park, E.S., Rose, S.A., Alibo, E., Sweeney, R., Dhainaut, M., Kobayashi, K.S., Sachidanandam, R., Baccarini, A., Merad, M., Brown, B.D.
Quiescent tissue stem cells evade immune surveillance
Immunity 2018 48(2):271-285.2017
2017
Yoshihama S, Vijayan S, Sidiq, T, Kobayashi, KS.
NLRC5/CITA: a key player in cancer immune surveillance.
Trends Cancer. 2017 Jan;3(1):28-38.
Pandey, A, Ding, S L, Qin, Q-M, Gupta, R, Gomez, G, Lin, F, Feng, X, da Costa, LF, Chaki, SP, Katepalli, M, Case, ED, van Schaik, EJ, Sidiq, T, Khalaf, O, Arenas, A, Kobayashi, KS, Samuel, JE, Rivera, GM, Alaniz, RC, Sze, S-H, Qian, X, Brown, WJ, Rice-Ficht, A, Russell, WK, Ficht, TA, and de Figueiredo, P.
Global Reprogramming of Host Kinase Signaling in Response to Fungal Infection.
Cell Host Micro. 2017 May 10;21(5):637-649.
Bist, P, Cheong, WS, Ng, A, Dikshit, N, Kim, BH, Pulloor, N, Khameneh, HJ, Matija Hedl, Shenoy, A, Balamuralidhar, V, Malik, N., Hong, M, Neutzner, A, Chin, K-C, Kobayashi, KS, Bertoletti, A, Mortellaro, A, Abraham, C, MacMicking, J, Xavier, R, and Sukumaran B.
E3 Ubiquitin ligase ZNRF4 negatively regulates NOD2 signalling and induces tolerance to MDP.
Nat Commun 2017 Jun 28;8:15865.
2016
Sidiq, T, Yoshihama, S, Downs, I, Kobayashi, KS.
Nod2: a critical regulator of ileal microbiota and Crohn’s disease.
Front Immunol, 2016 Sep 20;7:367.
Yoshihama S, Roszik J, Downs I, Meissner TB, Vijayan S, Chapuy B, Sidiq T, Shipp MA, Lizee GA, Kobayashi KS.
NLRC5/MHC class I transactivator is a target for immune evasion in cancer.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5999-6004.
Downs I, Vijayan S, Sidiq T, Kobayashi KS.
CITA/NLRC5: A critical transcriptional regulator of MHC class I gene expression.
Biofactors. 2016 Apr 18.
2015
Burrows MP, Volchkov P, Kobayashi KS, Chervonsky AV.
Microbiota regulates type 1 diabetes through Toll-like receptors.
Proc Natl Acad Sci U S A. 2016 May 24;113(21):5999-6004.
Shiu J, Piazuelo MB, Ding H, Czinn SJ, Drakes ML, Banerjee A, Basappa N, Kobayashi KS, Fricke WF, Blanchard TG.
Gastric LTi cells promote lymphoid follicle formation but are limited by IRAK-M and do not alter microbial growth.
Mucosal Immunol. 2015 Sep;8(5):1047-59
Miyata M, Lee JY, Susuki-Miyata S, Wang WY, Xu H, Kai H, Kobayashi KS, Flavell RA, Li JD.
Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M.
Nat Commun. 2015 Jan 14;6:6062.
2014
Lech M, Gröbmayr R, Ryu M, Lorenz G, Hartter I, Mulay SR, Susanti HE, Kobayashi KS, Flavell RA, Anders HJ.
Macrophage phenotype controls long-term AKI outcomes–kidney regeneration versus atrophy.
J Am Soc Nephrol. 2014 Feb;25(2):292-304.
2013
Shiu J, Czinn SJ, Kobayashi KS, Sun Y, Blanchard TG.
IRAK-M expression limits dendritic cell activation and proinflammatory cytokine production in response to Helicobacter pylori.
PLoS One. 2013 Jun 11;8(6):e66914.
Klimesova K, Kverka M, Zakostelska Z, Hudcovic T, Hrncir T, Stepankova R, Rossmann P, Ridl J, Kostovcik M, Mrazek J, Kopecny J, Kobayashi KS, Tlaskalova-Hogenova H.
Altered gut microbiota promotes colitis-associated cancer in IL-1 receptor-associated kinase M-deficient mice.
Inflamm Bowel Dis. 2013 May;19(6):1266-77.
Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C; Immunological Genome Consortium, Best AJ, Knell J, Goldrath A, Joic V, Koller D, Shay T, Regev A, Cohen N, Brennan P, Brenner M, Kim F, Nageswara Rao T, Wagers A, Heng T, Ericson J, Rothamel K, Ortiz-Lopez A, Mathis D, Benoist C, Bezman NA, Sun JC, Min-Oo G, Kim CC, Lanier LL, Miller J, Brown B, Merad M, Gautier EL, Jakubzick C, Randolph GJ, Monach P, Blair DA, Dustin ML, Shinton SA, Hardy RR, Laidlaw D, Collins J, Gazit R, Rossi DJ, Malhotra N, Sylvia K, Kang J, Kreslavsky T, Fletcher A, Elpek K, Bellemare-Pelletier A, Malhotra D, Turley S.
The transcriptional landscape of αβ T cell differentiation.
Nat Immunol. 2013 Jun;14(6):619-32. doi: 10.1038/ni.2590. Epub 2013 May 5. PMID: 23644507
Biswas A, Kobayashi KS.
Regulation of intestinal microbiota by the NLR protein family.
Int Immunol. 2013 Apr;25(4):207-14.
2012
Kobayashi KS, van den Elsen PJ.
NLRC5: a key regulator of MHC class I-dependent immune responses.
Nat Rev Immunol. 2012 Dec;12(12):813-20.
Lee KH, Biswas A, Liu YJ, Kobayashi KS.
Proteasomal degradation of Nod2 protein mediates tolerance to bacterial cell wall components.
J Biol Chem. 2012 Nov 16;287(47):39800-11.
Sukumaran B, Ogura Y, Pedra JH, Kobayashi KS, Flavell RA, Fikrig E.
Receptor interacting protein-2 contributes to host defense against Anaplasma phagocytophilum infection.
FEMS Immunol Med Microbiol. 2012 Nov;66(2):211-9.
Hoogerwerf JJ, van der Windt GJ, Blok DC, Hoogendijk AJ, De Vos AF, van ‘t Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.
Interleukin-1 receptor-associated kinase M-deficient mice demonstrate an improved host defense during Gram-negative pneumonia.
Mol Med. 2012 Sep 25;18:1067-75.
Koo JE, Hong HJ, Dearth A, Kobayashi KS, Koh YS.
Intracellular invasion of Orientia tsutsugamushi activates inflammasome in asc-dependent manner.
PLoS One. 2012;7(6):e39042.
Biswas A, Meissner TB, Kawai T, Kobayashi KS.
Cutting edge: impaired MHC class I expression in mice deficient for Nlrc5/class I transactivator.
J Immunol. 2012 Jul 15;189(2):516-20.
NOD2 signaling contributes to host defense in the lungs against Escherichia coli infection.
Theivanthiran B, Batra S, Balamayooran G, Cai S, Kobayashi K, Flavell RA, Jeyaseelan S.
Infect Immun. 2012 Jul;80(7):2558-69.
van der Windt GJ, Blok DC, Hoogerwerf JJ, Lammers AJ, de Vos AF, Van’t Veer C, Florquin S, Kobayashi KS, Flavell RA, van der Poll T.
Interleukin 1 receptor-associated kinase m impairs host defense during pneumococcal pneumonia.
J Infect Dis. 2012 Jun 15;205(12):1849-57.
Meissner TB, Liu YJ, Lee KH, Li A, Biswas A, van Eggermond MC, van den Elsen PJ, Kobayashi KS.
NLRC5 cooperates with the RFX transcription factor complex to induce MHC class I gene expression.
J Immunol. 2012 May 15;188(10):4951-8.
Meissner TB, Li A, Liu YJ, Gagnon E, Kobayashi KS.
The nucleotide-binding domain of NLRC5 is critical for nuclear import and transactivation activity.
Biochem Biophys Res Commun. 2012 Feb 24;418(4):786-91.
Meissner TB, Li A, Kobayashi KS.
NLRC5: a newly discovered MHC class I transactivator (CITA).
Microbes Infect. 2012 Jun;14(6):477-84.
Kobayashi KS.
NLRC5/CITA: a novel regulator of class I major histocompatibility complex genes.
J immunodefic Disord. 2012;1(1). pii: 1000e102.
Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M.
TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2.
Proc Natl Acad Sci U S A. 2012 Jan 24;109(4):E177-86.
Zhao Y, Alonso C, Ballester I, Song JH, Chang SY, Guleng B, Arihiro S, Murray PJ, Xavier R, Kobayashi KS, Reinecker HC.
Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1.
Inflamm Bowel Dis. 2012 Apr;18(4):603-12.
2011
Ogawa C, Liu YJ, Kobayashi KS.
Muramyl dipeptide and its derivatives: peptide adjuvant in immunological disorders and cancer therapy.
Curr Bioact Compd. 2011 Sep;7(3):180-197.
Caetano BC, Biswas A, Lima DS Jr, Benevides L, Mineo TW, Horta CV, Lee KH, Silva JS, Gazzinelli RT, Zamboni DS, Kobayashi KS.
Intrinsic expression of Nod2 in CD4+ T lymphocytes is not necessary for the development of cell-mediated immunity and host resistance to Toxoplasma gondii.
Eur J Immunol. 2011 Dec;41(12):3627-31.
Lech M, Kantner C, Kulkarni OP, Ryu M, Vlasova E, Heesemann J, Anz D, Endres S, Kobayashi KS, Flavell RA, Martin J, Anders HJ.
Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.
Ann Rheum Dis. 2011 Dec;70(12):2207-17.
Biswas A, Petnicki-Ocwieja T, Kobayashi KS.
Nod2: a key regulator linking microbiota to intestinal mucosal immunity.
J Mol Med (Berl). 2012 Jan;90(1):15-24.
Balamayooran T, Batra S, Balamayooran G, Cai S, Kobayashi KS, Flavell RA, Jeyaseelan S.
Receptor-interacting protein 2 controls pulmonary host defense to Escherichia coli infection via the regulation of interleukin-17A.
Infect Immun. 2011 Nov;79(11):4588-99.
Petnicki-Ocwieja T, DeFrancesco AS, Chung E, Darcy CT, Bronson RT, Kobayashi KS, Hu LT.
Nod2 suppresses Borrelia burgdorferi mediated murine Lyme arthritis and carditis through the induction of tolerance.
PLoS One. 2011 Feb 28;6(2):e17414.
Biswas A, Wilmanski J, Forsman H, Hrncir T, Hao L, Tlaskalova-Hogenova H, Kobayashi KS.
Negative regulation of Toll-like receptor signaling plays an essential role in homeostasis of the intestine.
Eur J Immunol. 2011 Jan;41(1):182-94.
Lee KH, Liu YJ, Biswas A, Ogawa C, Kobayashi KS.
A novel aminosaccharide compound blocks immune responses by Toll-like receptors and nucleotide-binding domain, leucine-rich repeat proteins.
J Biol Chem. 2011 Feb 18;286(7):5727-35.
2010
Berglund M, Melgar S, Kobayashi KS, Flavell RA, Hörnquist EH, Hultgren OH.
IL-1 receptor-associated kinase M downregulates DSS-induced colitis.
Inflamm Bowel Dis. 2010 Oct;16(10):1778-86.
Frutuoso MS, Hori JI, Pereira MS, Junior DS, Sônego F, Kobayashi KS, Flavell RA, Cunha FQ, Zamboni DS.
The pattern recognition receptors Nod1 and Nod2 account for neutrophil recruitment to the lungs of mice infected with Legionella pneumophila.
Microbes Infect. 2010 Oct;12(11):819-27.
Biswas A, Liu YJ, Hao L, Mizoguchi A, Salzman NH, Bevins CL, Kobayashi KS.
Induction and rescue of Nod2-dependent Th1-driven granulomatous inflammation of the ileum.
Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14739-44.
Koh YS, Koo JE, Biswas A, Kobayashi KS.
MyD88-dependent signaling contributes to host defense against ehrlichial infection.
PLoS One. 2010 Jul 23;5(7):e11758.
Meissner TB, Li A, Biswas A, Lee KH, Liu YJ, Bayir E, Iliopoulos D, van den Elsen PJ, Kobayashi KS.
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes.
Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13794-9.
Hubbard LL, Ballinger MN, Thomas PE, Wilke CA, Standiford TJ, Kobayashi KS, Flavell RA, Moore BB.
A role for IL-1 receptor-associated kinase-M in prostaglandin E2-induced immunosuppression post-bone marrow transplantation.
J Immunol. 2010 Jun 1;184(11):6299-308.
Charrière GM, Ip WE, Dejardin S, Boyer L, Sokolovska A, Cappillino MP, Cherayil BJ, Podolsky DK, Kobayashi KS, Silverman N, Lacy-Hulbert A, Stuart LM.
Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.
J Biol Chem. 2010 Jun 25;285(26):20147-54.
Archer KA, Ader F, Kobayashi KS, Flavell RA, Roy CR.
Cooperation between multiple microbial pattern recognition systems is important for host protection against the intracellular pathogen Legionella pneumophila.
Infect Immun. 2010 Jun;78(6):2477-87.
Silva GK, Gutierrez FR, Guedes PM, Horta CV, Cunha LD, Mineo TW, Santiago-Silva J, Kobayashi KS, Flavell RA, Silva JS, Zamboni DS.
Cutting edge: nucleotide-binding oligomerization domain 1-dependent responses account for murine resistance against Trypanosoma cruzi infection.
J Immunol. 2010 Feb 1;184(3):1148-52.