Welcome to our lab!
Greetings
Our laboratory is mainly focusing on the research of MHC class I gene expression and the innate immune system, but other topics may include receptor signals of innate immune system, inflammatory diseases, immune cancer, development of new biomarkers, and cancer immunotherapy.
To find out about more of our research, please click here.
Research Highlight ::Recent Press-Release information::
1.Enhancing the immune system's ability to detect cancer
A new technology to increase visibility of cancer cells to the immune system using CRISPR has been developed, and could lead to a new way to treat cancer.
(Picked up by more than 53 websites of news and blogs worldwide!)
2. New findings of controllable regulator of CIITA, and for immune system
Our findings of CIITA-binding protein identified FBOX11, elucidate molecular mechanism that regulates CIITA at the protein level and determine MHC-II expression level. This finding may provide a future therapeutic target for inflammatory diseases and cancer.
3. How SARS-CoV-2 escapes from our immune system?
We have identified a key mechanism used by the SARS-CoV-2 virus to evade host immune systems. The paper was published in the Nature Communications.
Latest News
Members
MHC Class I
MHC Class I
MHC (Major Histocompatibility Complex) is the most important molecule in modern medicine, for which the Nobel prize was awarded three times to 6 scientists. We discovered a master regulator of MHC class I gene expression called NLRC5 or CITA (MHC class I transactivator). This finding is important for infectious diseases, cancers and tissue transplantation.
Crohn's Disease
Crohn's Disease
Crohn’s disease is a chronic inflammatory disease of the intestines. Currently, there is no medication that can cure this deleterious disease. NOD2 is the most frequently mutated gene in patients afflicted with Crohn’s disease. Our group has discovered the function of NOD2 in the intestines.
